The materials we have in our lap is SMOOTH-ON SORTA-ClearTM 37 silicon, and Smooth-Cast™ 325, plastic. both materials from the same manufacturers and have similar safety requirements.
Reading through the specification sheet, the safety equipment needed is gloves and eye protection.
Key differences between the two materials in casting is that the silicon material takes 4 hours to cure, while the plastic takes only 10 minutes.